COMPLEX GENETIC AND EPIGENETIC REGULATION DEVIATES GENE EXPRESSION FROM A UNIFYING GLOBAL TRANSCRIPTIONAL PROGRAM.

Complex genetic and epigenetic regulation deviates gene expression from a unifying global transcriptional program.

Environmental or genetic perturbations lead to gene expression changes.While most analyses of these changes emphasize the presence of qualitative mama mellace s mores differences on just a few genes, we now know that changes are widespread.This large-scale variation has been linked to the exclusive influence of a global transcriptional program dete

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Metal-soil interface adhesion in clay clogging during shield tunneling: Theoretical model and experimental validation

Clogging is a major geohazards risk in mechanized tunnelling through cohesive soils.Clay clogging results from the high adhesion between the clay and metal.Based on the water film theory and Reynolds fluid equation, the interfacial adhesion between metal and soil is simplified in this study as viscous hydrodynamic behavior between planes.Considerin

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Planning on the Verge of AI, or AI on the Verge of Planning

The urban planning solar filter 55mm process is complex, involving social, economic, environmental, and political systems.Knowledge of how these systems interact is the domain of professional planners.Advances in artificial intelligence (AI) present planners with a ripe opportunity to critically assess their approaches and explore how new data coll

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